货号：G801018
简介：
免疫球蛋白E抗体，Mouse anti-Human IgE Antibody, IgE抗体，过敏源总IgE检测原材料
IgE是由ε重链恒定区定义的单体型免疫球蛋白，分子量约190kDa，无铰链区，含4个CH结构域，血清丰度为五类免疫球蛋白中最低（仅为IgG的1/300），血浆半衰期约2~2.5天，主要由黏膜相关淋巴组织浆细胞合成，是介导Ⅰ型速发型超敏反应的核心效应抗体，也是过敏性疾病、寄生虫感染、免疫缺陷病的关键体液标志物
IgE临床检测分为总IgE与特异性IgE两类，总IgE代表人体全部IgE抗体总量，常用于过敏体质初筛；特异性IgE是针对某一种过敏原（尘螨、鸡蛋、花粉等）的抗体，用来定位具体致敏物质，指导过敏原规避或脱敏治疗方案制定。
其它名称：Immunoglobulin E antibody, IgE antibody
货号：G801018
种类：抗体
应用：CLIA
特异性：Human Immunoglobulin E
来源：mAb
存贮：-20℃
产品说明
IgE is most commonly associated with allergic disease and thought to mediate an exaggerated and/or maladaptive immune response to antigens. Once antigen specific IgE has been produced, re-exposure of the host to that particular antigen results in the typical immediate hypersensitivity reaction. This reaction occurs within minutes of exposure to the offending agent; these immediate effects include: hypotension, bronchospasm, urticaria, vomiting, diarrhea, and others. While preformed chemicals mediate the immediate hypersensitivity reaction, de novo production of other mediators, instigated by cross-linking of IgE-FcεRI, result in a late phase allergic response. This late phase response is thought to represent the inflammation in chronic allergic diseases; as a result, both the immediate and late phase responses are mediated by downstream effects of IgE.
This product is for research use only. It is not intended for diagnostic or therapeutic use.
立即扫码 | 微信咨询
