IgG4抗原

货号：G7043

简介：
IgG4抗原，IgG4 antigen
Immunoglobulin G4 (IgG4) is the least abundant subclass of IgG, playing a role in the activation of antibody-dependent immune effector responses. Raised serum IgG4 levels occur in healthy individuals and in response to various stimuli, including allergens, parasites, autoimmune reactions, and malignancy. IgG4-related disease was first identified in 2001 and is an idiopathic, chronic, fibro-inflammatory disease characterized by the infiltration of tissues and organs by T and B lymphocytes, IgG4-secreting plasma cells, and varying degrees of fibrosis, which responds to oral steroid therapy. Sites affected include salivary glands, lungs, kidneys, orbit and lacrimal glands, pancreas, biliary system, and retroperitoneum