NGAL抗原

其它名称：NGAL antigen，human NGAL protein

货号：N7012

种类：抗原

应用：standard

特异性：Human NGAL

来源：E. coli

存贮：-20℃

产品说明

NGAL（Neutrophil Gelatinase‑Associated Lipocalin），即中性粒细胞明胶酶相关脂质运载蛋白，别名Lipocalin‑2（LCN‑2），由LCN2基因编码，属于脂质运载蛋白超家族，是急性肾损伤（AKI）核心肾小管结构损伤生物标志物，也是目前肾脏领域应用成熟的外周血/尿液靶标。生理状态下NGAL低水平组成型表达，参与铁稳态调控、固有免疫抑菌、细胞外基质重塑；在缺血、毒素、炎症刺激下NF‑κB通路激活，肾小管上皮细胞、活化中性粒细胞快速大量合成释放NGAL，

Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a member of the lipocalin iron-carrying protein family expressed in a variety of tissues including neutrophils, kidney, and cardiomyocytes. At steady state plasma and urinary NGAL concentrations are negligible. Plasma and urinary levels are increased in both acute kidney injury and CKD. Elevated plasma NGAL is a strong predictor of acute kidney injury.