鼠抗人PTH抗体

货号：grPT101

简介：
parathyroid hormone (PTH), substance produced and secreted by the parathyroid glands that regulates serum calcium concentration.Under the microscope the PTH-producing cells, called chief cells, isolated from the parathyroid glands, occur in sheets interspersed with areas of fatty tissue. Occasionally the cells are arranged in follicles similar to but smaller than those present in the thyroid gland. As with other protein hormones, PTH is synthesized as a large inactive prohormone. At the time of secretion the prohormone is split, and the active hormone (a protein containing 84 amino acids) is released from the inactive precursor.

The major determinant of PTH secretion is the serum concentration of ionized calcium. Serum calcium concentration is monitored by calcium-sensing receptors located on the surface of the parathyroid cells. When serum calcium concentrations increase, more calcium binds to the receptors, causing a decrease in parathyroid hormone secretion. Conversely, when serum calcium concentrations decrease, decreased calcium receptor binding causes an increase in PTH secretion. Magnesium controls parathyroid hormone secretion in a similar fashion.