甲状腺过氧化物酶（TPO）抗体

货号：grTP01

简介：
Thyroid peroxidase (TPO) is a key enzyme in thyroid hormone biosynthesis. It catalyzes both iodination and coupling of iodotyrosine residues in TG. Human TPO is located on chromosome 2p25, with 17 exons. The mRNA is about 3 kb encoding a thyroid-specific glycosylated hemoprotein of 110 kDa bound at the apical membrane of thyrocytes. The majority of patients with congenital hypothyroidism have defects in the synthesis or iodination of TG that are attributable to TPO deficiency. Subnormal or absence of TPO activities results in thyroid iodide organification giving rise to goitrous congenital hypothyroidism. Total iodide organification defect (TIOD) is inherited in an autosomal recessive mode.甲状腺过氧化物酶(Thyroid peroxidase, TPO)是一种糖化血红蛋白，位于甲状腺细胞的顶膜上，催化碘化物氧化并进一步并入甲状腺球蛋白分子。TPO与乳酸过氧化物酶、髓过氧化物酶和嗜酸性粒细胞过氧化物酶具有序列同源性。hTPO-1和hTPO-2两种异构体已被分离出来，后者被截断，缺乏酶活性。TPO也是一种主要的甲状腺抗原，每当对甲状腺的耐受性被破坏时，免疫反应就指向TPO。TPO变异与自身免疫性甲状腺功能减退有关。