丙戊酸（VPA）抗体

其它名称：丙戊酸单抗，鼠抗VPA抗体,valproic acid Antibody

货号：grVA101

种类：抗体

应用：POCT，LITIA

特异性：valproic acid

来源：Mouse

存贮：-20℃

产品说明

Valproic acid was initially discovered in 1882 and was used as an inert solvent until 1962, when its antiepileptic properties were discovered by means of the Khellin derivative trial.In 1966 it was trialed as a mood stabilizer with great success and was eventually approved by the FDA in 1994 when it was compared to lithium for the treatment of bipolar disorder.
Valproic acid’s main antiepileptic mechanism of action is T-calcium channel blockade, as well as some mild sodium channel blockade. Lastly, valproic acid also blocks histone deacetylase 1 which prevents the acetylation of genes associated with inflammatory transcription. Valproic acid is considered a first line treatment for bipolar disorder and acute mania and is comparable to lithium.Valproic acid has also been used off label to address impulsivity and agitation post traumatic brain injury.
Valproic acid (VPA) ia as a highly prevalent medication with multifaceted therapeutic applications in various neurological and psychiatric disorders. The therapeutic uses of VPA include epilepsy treatment across different seizure types, bipolar disorder management, and migraine prophylaxis. The mechanism of action for VPA involves the enhancement of inhibitory neurotransmission and the modulation of voltage-gated ion channels.