货号：grVA101
简介：
鼠抗丙戊酸单抗，Mouse anti valproic acid Antibody
Valproic acid (VPA) was initially synthesized in 1882 by Burton as a derivative of valeric acid, which is a branched, short-chain, and naturally occurring fatty acid present in both plants and animals. However, the anticonvulsant properties of VPA were discovered by Eymard in 1962 while attempting to synthesize new compounds from VPA.
其它名称：丙戊酸单抗，鼠抗VPA抗体,valproic acid Antibody
货号：grVA101
种类：抗体
应用：POCT，LITIA
特异性：valproic acid
来源：mAb
存贮：-20℃
产品说明
丙戊酸（VPA）属于小分子脂肪酸类药物，治疗窗窄（50–100μg/mL）、个体代谢差异大、肝毒性与血药浓度直接相关，血药浓度监测（TDM）是临床用药安全的核心刚需。IVD免疫法是目前医院检验科主流的VPA定量检测方案，相较于液相色谱质谱（LC-MS/MS），具备自动化程度高、检测速度快、通量高、适配常规生化发光平台的优势，是抗癫痫药物治疗药物监测的核心配套体外诊断技术，广泛用于神经内科、精神科、儿科个体化用药指导。
Valproic acid was initially discovered in 1882 and was used as an inert solvent until 1962, when its antiepileptic properties were discovered by means of the Khellin derivative trial.In 1966 it was trialed as a mood stabilizer with great success and was eventually approved by the FDA in 1994 when it was compared to lithium for the treatment of bipolar disorder.
Valproic acid’s main antiepileptic mechanism of action is T-calcium channel blockade, as well as some mild sodium channel blockade. Lastly, valproic acid also blocks histone deacetylase 1 which prevents the acetylation of genes associated with inflammatory transcription. Valproic acid is considered a first line treatment for bipolar disorder and acute mania and is comparable to lithium.Valproic acid has also been used off label to address impulsivity and agitation post traumatic brain injury.
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