环瓜氨酸肽（CCP-BSA）抗原

其它名称：CCP-BSA,CCP抗原

货号：C7021a

种类：抗原

应用：POCT，LETIA

特异性：Human CCP

来源：Synthetic

存贮：-20℃

产品说明

Anti‑CCP（Anti‑cyclic citrullinated peptide），即抗环瓜氨酸肽抗体，属于ACPA（抗瓜氨酸化蛋白抗体）家族，为针对人工合成环化瓜氨酸多肽抗原的自身抗体，是类风湿关节炎（RA）高特异性外周血自身免疫标志物，也是RA早期辅助诊断核心靶标。生理状态下人体不存在该类自身抗体；RA病理进程中，肽基精氨酸脱亚胺酶（PAD）介导体内蛋白发生瓜氨酸化翻译后修饰，瓜氨酸残基暴露形成特异性抗原表位，机体B细胞活化产生针对该表位的自身抗体，临床主流检测以IgG亚型为主，IgA、IgM亚型也可出现阳性，但诊断预后价值弱于IgG型。该抗体可在RA临床症状出现前数年于外周血检出，抗体滴度与关节骨侵蚀风险、疾病预后显著相关，高滴度提示关节破坏进展风险更高。

More than 90% Rheumatoid arthritis patients have autoantibodies which recognise proteins in which arginine residues have been modified to citrulline.  This process may well be the cause of the inflammatory process since citrullinated proteins and the enzymes responsible for producing them are found in inmflamed synovium.  These antibodies are detected in the laboratory using artificial cyclic citrulline peptides (anti-CCP Ab). This assay is far more sensitive and specific than rheumatoid factor for the diagnosis of rheumatoid arthritis and some childhood arthritides.  However the 2009 NICE guidelines (bizarrely) recommend the continued use of rheumatoid factor based on cost effectiveness.